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Offering Hope to Millions: A New Hepatitis Drug

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Photo by Ivan Samkov from Pexels

Amidst all the recurring tragedies of the COVID-19’s pandemic, a breakthrough discovery in the health sector is always a cause for celebration. For years, hepatitis disease has infected millions of people around the globe, and science was barely able to give the patients a tangible sentiment of hope. However, the new lifesaving Mellesyan drug is now offering millions an accessible, effective, and affordable treatment. 

Hepatitis C

The Hepatitis virus is a disease infecting almost 71 million people from all around the world, though it is mainly dominant in Africa. This silent virus starts by attacking the liver, causing fatal liver diseases, such as cirrhosis and cancer. Thus, the virus reaps the lives of almost 1.4 million patients annually. 

Since the virus is bloodborne, most infections are spread via blood exposure means, including the sharing of injection equipment, reuse or inadequate sterilization of medical equipment, transfusion of unscreened blood and blood products, or sexual practices that can lead to blood exposure.

History of treatments

Despite its severeness, scientists were unsuccessful in discovering a vaccine. Thus, in the past two decades, doctors relied on a combination of drugs to treat this illness. Yet, not only does that treatment rely on weekly injections, but it also causes adverse side effects, which can continue prevailing even after the end of the treatment. Further, reports prove that this treatment was only able to help between 40% and 65% of the infected populace. 

As the years passed, scientists developed direct-acting antivirals to combat this illness. However, even though it succeeded in curing the disease at a very high rate, it remained inaccessible to most patients because of its expensiveness. 

“Hepatitis C medicines have always been very expensive in the Western Pacific region because we have only high- and middle-income countries, as categorized by the World Bank,” explained Dr. Po-Lin Chan, the WHO’s medical officer for viral hepatitis.

A new, affordable drug

2021 marks a revolutionary event in the health sector, as Malaysia registers the world’s first affordable and effective Hepatitis drug. “We decided to work with middle-income countries to try to develop an effective treatment,” declared Jean-Michel Piedagnel, director of DNDi Southeast Asia. “We started the clinical trial in Malaysia and Thailand saying we are also going to put on the market an affordable treatment.”

Thus, with the aid of Egyptian drugmaker, Pharco Pharmaceuticals, the non-profit organization is bringing the combined treatment of two hepatitis C tablets, Ravidasvir ­­and Sofosbuvir, to the public. Not only did DNDi report that this treatment has a success rate of 97%, but it is also very affordable in comparison to the other drugs.

While the alternative drugs used to cost up to $84,000 per treatment, the Malaysian drugs will cost almost $300. Moreover, the treatment will span over the course of 12 weeks, making the cost of the treatment $3.50 per day. 

Between patents and international laws

Perhaps one of the main reasons Malaysia was able to achieve this admirable result is the ongoing pandemic. Through legal conditions of the clinical trial, Malaysia took a controversial step and bought Sofosbuvir at an affordable price via Egypt. Then in 2017, the country issued a compulsory license for sofosbuvir, allowing the import of the drug to the country. A decision that was deemed risky at the time.

“In international law, if the product is patented, and a country wants to use that product for public non-commercial use, if it’s a situation of urgency, then there is no need to go and negotiate first with the patent holder,” said Chee Yoke Ling, an international lawyer and executive director of Third World Network, a Malaysian research and advocacy organization. “In Malaysia, our laws implement that as the rights of the government.”

“What happened in Malaysia provides a useful example for other countries. There could be an opportunity to advance the reduction of intellectual property provisions that don’t benefit countries as there’s a shift in how these superpowers are thinking about intellectual property. For example, the US endorsing the TRIPS waiver for COVID-19 technologies,” said Fifa Rahman, who ran hepatitis C advocacy efforts at the Malaysian AIDS Council in 2016 and is now working on the ACT-Accelerator for the global COVID-19 response.

References:
Al Jazeera. (2021, July 28). Affordable hepatitis drug offers new hope to millions. Health News | Al Jazeera. https://www.aljazeera.com/news/2021/7/28/affordable-hepatitis-drug-offers-new-hope-to-millionsHepatitis C in Malaysia: From crisis to hope. (2020, July 28). WHO. https://www.who.int/malaysia/news/detail/28-07-2020-hepatitis-c-in-malaysia-from-crisis-to-hopeKollewe, J. (2020, October 15). Non-profit’s $300 hepatitis C cure as effective as $84,000 alternative. The Guardian. https://www.theguardian.com/science/2018/apr/12/non-profits-300-hepatitis-c-cure-as-effective-as-84000-alternativeMcLauchlan, J. (2021, May 2). New drugs work against the many strains of hepatitis C found in African countries. The Conversation. https://theconversation.com/new-drugs-work-against-the-many-strains-of-hepatitis-c-found-in-african-countries-159462

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Homes Taken, Gates Closed: A Week That Shook Jerusalem

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Jerusalem witnessed two deeply unfortunate and consequential developments in the same week. In Occupied East Jerusalem, eleven Palestinian families were evicted from their homes by the Israeli Defence Forces (IDF). At the same time, access to one of the holiest sites for Muslims, Al Aqsa Mosque, was blocked. The gates of the mosque were closed, with only the possibility of a limited entry.

These are not isolated events but a continuity of Israel’s blatant attacks on the civilian population of Palestine. The complete obliteration of Gaza is evidence of a broader plan of Israel to completely devastate the Palestinian homeland. Through these heinous actions, land, identity, and access to sacred places remain at the center of tensions.

Forced Evictions in East Jerusalem

According to credible sources, 11 Palestinian families were removed from their homes in East Jerusalem, an area Israel has controlled since 1967 and which is widely regarded under international law as occupied territory.

For many of these families, the homes were not temporary shelters. They had lived there for decades. Their eviction meant more than relocation, but it meant the loss of stability, community, and long-standing ties to the area.

Data from the United Nations Office for the Coordination of Humanitarian Affairs shows that hundreds of Palestinians face eviction threats in East Jerusalem each year. These cases often emerge from legal disputes over property ownership. However, the broader pattern has drawn sustained international concern.

Such evictions contribute to a gradual displacement of Palestinian residents from key areas of the city.

The Legal and Political Reality of East Jerusalem

The status of East Jerusalem remains one of the most sensitive issues. While Israel considers the entire city its capital, Palestinians view East Jerusalem as the future capital of their state. International law largely treats the area as occupied territory by Israel.

Property disputes in East Jerusalem are often shaped by a complex legal framework. In many cases, Israeli law allows claims based on historical ownership that are difficult for Palestinian residents to contest. At the same time, Palestinians face significant barriers when attempting to reclaim property lost decades ago.

The result is a system that favours Israel in the demographic balance, contributing to ongoing tensions in the entire region.

The Plight of Al-Aqsa Mosque

Especially during the holy month of Ramadan, hundreds of thousands of Palestinians attend prayers at Al-Aqsa mosque. However, during this Ramadan, Israeli authorities limited entry to the mosque compound, including the closure of gates and restrictions on who could enter. These measures came during a time when thousands of worshippers would normally gather.

Al-Aqsa holds immense religious significance. It is considered the third holiest site in Islam, after Makkah and Madinah. For Muslims worldwide, it is not only a place of worship but a symbol of spiritual and historical identity.

Ultimately, when access is restricted, the impact is felt far beyond Jerusalem. It resonates across the global Muslim community.

A Broader Pattern of Genocidal Mindset

With more than 77,000 killings in the Gaza Strip, including women and children, Israel is acting on a strategy to completely wipe out the Palestinian population. The closure of mosques and evictions is the continuation of the genocidal mindset.

Such restrictions are often justified on security grounds. However, the repeated nature of these measures creates a pattern that affects freedom of worship.

During major religious periods, when attendance typically rises, these restrictions carry even greater significance.

International Reaction

In the wake of these heinous events, Muslim-majority nations publicly condemned the closure of Al-Aqsa’s gates. Statements described the move as a violation of religious rights and called for unrestricted access to the mosque.

These reactions reflect the broader importance of Jerusalem in the entire world.

Jerusalem has long been a focal point of political, religious, and historical tension. The events of this week show how quickly these elements can converge.

As debates continue over sovereignty, security, and rights, one question remains central: Can a city of such deep religious and historical importance sustain balance when both homes and holy sites remain contested? Can a city of Holy sites bear the wrath of a country that is deeply involved in genocide?

The answer to that question will continue to shape not only Jerusalem’s future, but also its place in the wider world.

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Inside the Plan to Disarm Hamas and Reshape Gaza’s Future

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Since the start of the Iran war, the first-ever formal meeting was conducted between Hamas and the “Board of Peace” during the second week of March. Israel also pledged to open the only pedestrian crossing between Gaza and Egypt during the month, but their promises have always been fabricated.

However, this announcement is a direct result of the meeting between Hamas and the United States. US President Donald Trump described the Gaza plan as the flagship initiative for the revitalization of the Middle East. However, the Middle East has also been turned into flames by the same President and Israel.

Recent Developments in Gaza

On the other hand, Hamas representatives clearly intimated to the Board of Peace that they would back away from their promises if Israel continued to oppress people and maintain restrictions imposed during the Iran war.

One of the most crucial events in Gaza is the closure of the Rafah border – the only crossing between Gaza and Egypt. Although the border was partially reopened for a limited supply of goods, the sole pedestrian crossing was closed. People in the West Bank, as well as in Gaza, are still under constant threat of being brutally killed, as observed during the ongoing genocide.

The Recent Meeting between Hamas and the Board of Peace

During the latest meetup between Hamas and the United States-led Board of Peace, a lot of demands were put in front of Hamas. One of the most prominent demands is that Hamas would be forced to allow the destruction of its vast Gaza tunnel network. This network is the primary source of Hamas operations and self-defence.

US President Donald Trump also put a plan to disarm Hamas completely and expected them to lay down their weapons in stages over the next eight months. A US-backed committee of Palestinian technocrats will be taking control of the overall security of Gaza. It is also planned that Israeli forces will withdraw from Gaza once they verify that Gaza is completely free from weaponry.

Dismantling the entire military structure of Hamas is another big demand put by the Board of Peace. The tunnel network is not just being used for operational scenarios, but it is also being used for aid supply, movement under blockade, and other defensive operations.

The Perspective of Hamas

Hamas, on the other hand, aptly understands the situation and the hollow promises of Israel and the United States. It has not publicly commented on the proposed disarmament plan.

The proposed Trump plan includes two primary components: a 12-point document including steps to implement Trump’s plan and a five-stage timeline. This timeline consists of plans for Hamas to surrender over the next eight months. Hamas adequately knows about the consequences if it leaves the field.

One Authority, One Law, and One Weapon

This is the motto of the document proposed by Donald Trump in his peace plan. It also states that only the individuals verified by the NCAG will be allowed to possess weapons. Resultantly, all armed factions need to cease military activities in all capacities.

This disarmament process will also be overseen by a weapons collection verification committee. In a nutshell, this motto clearly defines the motto of the US to completely take over Gaza. There should not be anything except the indirect rule of the United States and the direct rule of Israel.

The Waves of the Iran War

The war involving Iran has not brought any real pause to Gaza; instead, increased assault has been observed. Israeli strikes have continued across the territory even as the wider regional conflict unfolded.

The current framework for Gaza traces back to an October ceasefire, after which Israel retained control over more than half of the enclave. Meanwhile, the vast majority of Gaza’s population, over two million people, has been pushed into a densely packed area still under Hamas administration.

In the weeks before tensions with Iran escalated, the plan appeared to be gaining ground. There were renewed discussions around reconstruction efforts and even the possible reopening of the Rafah crossing, raising cautious hopes of relief for Gaza’s population.

However, the situation on the ground has remained extremely volatile. Israeli forces (IDF) have continued their operations, including recent strikes that killed at least 12 people, among them several police personnel. Israel has maintained that such actions are carried out in response to threats or attacks linked to Hamas.

Officials familiar with negotiations in Cairo suggest that Hamas views the regional conflict as a turning point. There is a belief within the group that Israel may be using the Iran war as an opportunity to step back from earlier commitments made under the Gaza plan, which is a claim Israel strongly denies.

Moreover, a key element of the proposal has been the question of disarmament. The idea centers on Hamas giving up its weapons in exchange for guarantees such as amnesty, with the expectation that this would open the door to reconstruction and a gradual withdrawal of Israeli forces.

Even so, it remains unclear whether this issue will be formally addressed or if it is just a form of manipulation, as Israel has been doing for decades.

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Militias, Fragmentation, and Escalation Across Palestinian Territories

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When Israel and the United States launched a full-scale military assault against Iran, international attention shifted instantly toward the possibility of a wider Middle Eastern War. The blockage of the Strait of Hormuz, the reluctance of the US and Israel to completely obliterate Iran and wipe out their leadership, are not just threats to the Middle East but to the entire world.

Currently, headlines are focusing on missiles, regional alliances, and the risk of escalation between powerful adversaries. On the other hand, the situation across the Palestinian territories did not pause. Instead, a series of heinous developments inside Gaza and the occupied West Bank reveal that the genocide is entering a new and increasingly complex phase.

Some of the recent trends reshaping the reality across Palestinian territories include the rise of militias, fragmentation inside the Gaza Strip, and intensified violence across the West Bank.

Together, these developments suggest that the genocide is evolving into a more layered and unpredictable struggle.

The Emergence of Israeli-Backed Militias in Gaza

One of the most striking developments in recent weeks is the rise of armed Palestinian factions operating inside Gaza with apparent coordination with Israeli forces.

In this context, several groups have begun carrying out operations targeting Hamas members and infrastructure within areas of Gaza under Israeli military control.

Among the groups identified are organizations known as the Popular Army, including Northern Forces and the Free Homeland Forces, which are believed to be connected to a broader network sometimes referred to as the Popular Forces.

Moreover, these militias have carried out activities in Gaza, including:

  • Raids on different locations
  • Abductions of civilians
  • Intelligence gathering operations for Israel

Their presence introduces a new dimension to the conflict. For years, the main dynamic inside Gaza has centered on the confrontation between Israeli forces and Hamas. The appearance of armed Palestinian factions aligned against Hamas complicates that structure and adds the possibility of internal fragmentation.

Security analysts warn that such developments can significantly reshape power dynamics within genocidal zones, bringing further instability and chaos.

Fragmentation of Governance Inside Gaza

The prolonged genocide and the destruction of infrastructure across the enclave have weakened administrative structures and complicated governance.

Several factors now contribute to the fragmentation of authority:

  • The continued presence of Israeli military operations in Gaza
  • The emergence of new armed factions operating independently
  • The erosion of centralized administrative control due to the scale of genocide

The introduction of additional militias may further complicate efforts to establish political stability in the territory. In many genocidal zones, the proliferation of armed groups often leads to competing spheres of influence and weakened governance structures.

Ultimately, this fragmentation could make future political settlements even more difficult, as multiple actors compete for influence within the territory.

Escalation in the West Bank

The West Bank is not immune to the genocidal activities of Israel. While Gaza and Iran remain at the center of international attention, the occupied West Bank has also experienced a dramatic increase in violence since the Gaza genocide began.

According to figures cited by Palestinian authorities and international observers, more than 1,000 Palestinians have been killed in the West Bank since the beginning of the Gaza genocide.

The violence has taken several forms, such as Israeli military raids in Palestinian towns and refugee camps, armed confrontations between Palestinian militants and Israeli forces, and attacks by Israeli settlers on Palestinian communities.

In recent months, numerous Palestinian villages have reported raids in which homes were damaged, vehicles burned, and farmland destroyed. Some incidents have also led to the displacement of families from rural areas.

Settler Violence and Community Displacement

Settler violence has become one of the most significant sources of instability in the West Bank.

There is a growing number of incidents involving attacks on Palestinian property and agricultural land.

These incidents include:

  • Destruction of olive groves and crops
  • Arson attacks targeting homes and vehicles
  • Confrontations between settlers and residents

The consequences extend beyond the immediate damage. In some cases, Palestinian families have left villages after repeated attacks, contributing to gradual displacement in certain rural areas.

Gaza in the Context of a Wider Regional Conflict

The US, Israel–Iran confrontation has transformed the regional geopolitical landscape dramatically. Military tensions between these countries have raised fears of a broader Middle Eastern war involving multiple actors.

However, the conflict within Palestinian territories continues to evolve largely independent of the regional headlines. The recent closure of the Rafah border has triggered panic buying. Resultantly, the prices of food have skyrocketed. Moreover, the shortage of cooking gas triggered by Israel has also worsened living conditions.

Moreover, the emergence of militias, fragmentation of governance, and escalating violence suggest that the genocide is entering a phase of more destruction. Despite several calls by the United Nations to allow humanitarian aid into Gaza, the world is not paying heed to the innocent lives trying to survive each second there.

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